Thursday, December 07, 2006

New HDL-Raising Medication Stopped in It's Track

Physicians and patients had been anticipating the outcome of the investigation trials for torcetrapib, an experimental medication which increases HDL (high density lipoprotein) or good cholesterol levels. However, this week the trials were stopped by Pfizer due to a higher death rate in the subjects who took this medication as opposed to those who did not.

Torcetrapib had gained much attention recently because there are no therapies which substantially raise HDL levels. Unlike the other cholesterols, HDL, helps protect against heart disease. A low level of HDL, less than 40 mg/dL for men and less than 50 mg/dL for women, is considered to be a significant risk factor for heart disease.

Most of the cholesterol lowering medications that are available currently do not effect the HDL significantly--they mostly lower the bad cholesterol or LDL (low density lipoprotein) levels. The therapeutic options for raising HDL are limited and mainly consist of regular exercise and niacin which often is not tolerated due to its side effect of a severe flushing sensation after taking the pill.

Normally, I would consider an experimental drug to be too esoteric for a blog, but I have had several knowledgeable patients who have asked me about its availability. For now, it's back to the drawing board. Torcetrapib has been terminated.

References: please see specific links.

8 comments:

Anonymous said...

The statement,."There are no therapies that substantially raise HDL levels,.." is wholly inaccurate & misleading. HDL2 is the "game", total HDL is FAR less specific.
Real free-nicotinic acid containing medication:
IR-Immediate release Niacin & ER-Niacin [Niaspan], {NOT SR-Niacin "Low Flush" [hepatotoxic] or Nicotinamide / aka NO FLUSH = placebo for lipids}, raise HDL2 113% to 189%. Recent data shows that total-HDL increases for up to 3 years on niacin. ONLY niacin & endogenous estrogen have this effect. The HDL increase is a pattern change in the total-HDL, primarily thru accumulation of HDL2. This is THE gold standard in HDL treatment,..and with IR or ER [NOT SR], it is safe. Flushing, with an EXPERIENCED clincian, is easily managed and almost always transient, usually subsiding after the titration period. Niacin already has a preponderance of data for MI, Stroke, Mortality & also the same benefit in diabetics. Counterintuitive to old 'dogma'.
It may be 3 years, or more, before ANY other therapy that EQUALS niacin is available. Evidence based medicine, outcomes data, in NUMEROUS NIH studies has already proven it`s benefit. Clinicians 'stall' on this, largely due to their reluctance to spend the 2-3 minutes to coach the patient adequately to empower them to succeed.
YES, a high-maintenance drug.
NO,.. it actually IS worth the trouble.
NEW SKILL SET REQUIRED:
PATIENT EDUCATION.

Dr. Taraneh Razavi said...

Dear anonymous
I agree that Niacin is the best medication that we have at this time for raising HDL. I would be interested in you sharing your experience and referring me to the data that shows that there is a 189% increase in the levels.

Anonymous said...

There is no way that there are reproducible studies showing 189% increase in HDL- even at a year out. Also, for those of us with experience using Niacin this has not been seen clinically either.

I do agree that No-Flush (which costs more) is useless as it contains no free Niacin. And it does take some time to explain how best to take the medication.

I also agree that there is great outcome data with Niacin. However it also affects TG and LDL levels, particle size etc- we therefore can't attribute this data soley to the effect on HDL.

Finally the tone of the post was aggressive. This blog is a place where not only patients can be informed, but where other docs can discuss medical issues as professional colleagues...sharing the info.

Anonymous said...

PHORA-HR / SF-HR

cholesterol-lowering medication said...

companies marketing mineral makeups and also get the best bargains in mineral makeup you can imagine,
find aout how to consolidate your students loans or just how to lower your actual rates.,
looking for breast enlargements? in Rochester,
homeopathy for eczema learn about it.,
Allergies, information about lipitor,
save big with great bargains in mineral makeup,

change edition interviewing motivational people preparing second
,

interviewing motivational people preparing second time
,

interviewing people motivational preparing for a second time
,

black mold exposure
,

black mold exposure symptoms
,

black mold symptoms of exposure
,

free job interview questions
,

free job interview answers
,

interview answers to get a job
,

lookfor hair styles for fine thin hair
,

search hair styles for fine thin hair
,

hair styles for fine thin hair
,

beach resort in the philippines
,

great beach resort in the philippines
,

luxury beach resort in the philippines
,
iron garden gates, here,
iron garden gates,
wrought iron garden gates
, here
,
wrought iron garden gates
,
You: The Owner's Manual: An Insider's Guide to the Body That Will Make You Healthier and Younger
,
answer from more much,
eat eating mindless more than think we we why
,
la times classified,
new york times classified


texturizer,
texturizers here,
black hair texturizer,
find aout how care curly hair,
find about how to care curly hair,
care curly hair,
lipitor rash,
lipitor reactions,
new house ventura california,
the house new houston tx,
new house washington dc,
new house washington dc,
new house ventura california,
the house new houston tx,
the house new houston tx, that you ar looking for,
new house ventura california, you need to buy,
new house washington dc,

hair surgery transplant
,

air filter allergy
,

refurbished dell laptop computers
,

hair surgery transplant
,

air filter allergy
,

refurbished dell laptop computers
,

hair surgery transplant
,

air filter allergy
,

refurbished dell laptop computers
,

chocolate esophagus heartburn study
,

chocolate esophagus heartburn study
be informed,

digestion healing healthy heartburn natural preventing way
,

digestion healing healthy heartburn natural preventing way
,


Allergies, lipitor rash,
alcohol rash,
lipitor and alcohol,
lipitor alcohol,

natural remedies to aid healing of esophagus
,

chicory heartburn
,

effectiveness of zocor vs. lipitor
,

chocolate esophagus
,
southwestern wrought iron yard gate,
exterior iron gates,
oriental wrought iron gates,
powder coated iron garden fencing,

seyma said...

very thanks

Serigraf Baskı
İmalat Sanayi
Sigorta Acenteleri
Sigorta
Sigorta
Silah
Çiçek Sipariş
Skoda Servisi
Sondaj
Stiker Baskı
Fotoğraf Çekimi
Futbol
Spor
Sürücü Kursu
Süsleme
Süsleme
Suzuki Servisi
Tabela
Tabldot
Takip Sistemleri
Tamir
Tamir Atölyesi
Tamir Tadilat
Teknik Servis
Tamir Servisi
Tarım Hayvancılık
Tarım
Taşımacılık
Taşıma
Tata Servisi
Fiyat Teklifi
Tekstil
Tekstil Giyim
Tekstil Sanayi
Tel Çit
Telefon
Telefon Tamiri
Telefon Santrali
Tel Örme
Telsim

tax georgia said...

black mold exposure,black mold symptoms of exposure,wrought iron garden gates,your next iron garden gates, here,hair styles for fine thin hair,search hair styles for fine thin hair,night vision binoculars,buy, night vision binoculars,lipitor reactions,lipitor reactions,luxury beach resort in the philippines,beach resort in the philippines,homeopathy for baby eczema.,homeopathy for baby eczema.,save big with great mineral makeup bargains,companies marketing mineral makeups,prodam iphone praha,Apple prodam iphone praha,iphone clone cect manual,manual for iphone clone cect,fero 52 binoculars night vision,fero 52 night vision,best night vision binoculars,buy, best night vision binoculars,computer programs to make photo albums,computer programs, make photo albums,free printable tax forms,printable tax forms, free here,craftmatic adjustable air bedcraftmatic adjustable air bed, info hereboyd night air bedboyd night air bed, low priceair bed in wisconsinbest air beds in wisconsincloud air inflatable bedbest cloud air inflatable bedsportable sealy air bedportables, sealy air bedsaluminum rv luggage racksaluminum made, rv luggage racksair bed form raisedbest air beds form raisedsupport equipments aircraftbest support equipments for aircraftsinformercials bed airbest, informercials bed airmattress sized air bedsbest mattress sized air bedantique doorknob identificationantique doorknob, identification tipstroubleshooting dvd playertroubleshooting with the dvd playerflat panel television lcd versus plasmaflat panel television, lcd versus plasma pic the bestcauses of economic recessionwhat are the causes of economic recessionbed air foam adjustablebed air adjustable foam hoof prints antique and unusual equestrian printshoof prints, antique equestrian printsbuy adjustable air bedbuy the best adjustable air bedsair bedscanadian storesair beds, cheap canadian stores

MGOOD said...

There are several niacin studies, as well as a wealth of info re: niacin therapy at www.cholesterolscore.com