Monday, January 15, 2007

Parkinson's Disease Medications Associated with Cardiac Valve Dysfunction

Two commonly used medications for Parkinson's disease, pergolide (Permax) and cabergoline (Dostinex), have been shown to be associated with cardiac-valve dysfunction in 2 recent studies published in last week's The New England Journal of Medicine.

In one of the studies, 31 cases of new-onset cardiac-valve regurgitation were detected among 11,417 patients who were prescribed anti-Parkinson's-disease agents from 1988 to 2005.
Of the 31 cases, 6 had been receiving pergolide and 6 had been taking cabergoline in the previous 12 months. "Their adjusted valve-disease incidence rates were sharply and significantly increased compared with the remaining 19 cases who had not been receiving either drug or any other dopamine agonist ."

The other study
also showed that the prevalence of clinically significant valvular leakage and of valve-leaflet thickening was significantly increased among patients taking either pergolide or cabergoline, but not those receiving nonergot-derived agents compared with those in the control group.

Both of these drugs are dopamine agonists. Pergolide has been in use for many years and carbegoline is a relatively newer medication. However, unlike other dopamine agonists they also block the serotonin receptor 5-hydroxytryptamine 2B (5-HT2B). This is the same mechanism involved for the cardiac-valve dysfunction that was associated with the weight loss agent fenfluramine in the 1990's.

References: N Engl J Med. 2007;356:6-9, 29-38, 39-46.

5 comments:

Anonymous said...

cheap tramadol
cheap celebrex
cheap meridia
cheap fioricet
cheap valium
cheap zoloft
cheap cialis
cheap paxil
Diflucan Valtrex
cheap propecia

Anonymous said...

www.r10.net küresel ısınmaya hayır seo yarışması
www.r10.net küresel ısınmaya hayır seo yarışması
www.r10.net küresel ısınmaya hayır seo yarışması
Sağır Oda
dizi izle
www.r10.net küresel ısınmaya hayır seo yarışması

Anonymous said...

happy new year

Matbaa
Evden Eve Nakliyat
Silah
Temizlik Firmaları
İnşaat Yapı Firmaları
Özel Dedektif
Uçak Bileti
Kesintisiz Güç Kaynağı
Kesintisiz Güç Kaynağı
Vaillant Servisi
Volkswagen Servisi
Volvo Servisi
Vw Servisi
Yapı İnşaat
Yapı Malzemeleri
Mimar
Mimarlar
Mimarlık
Yapı Malzemeleri
Yapı Taahhüt İşleri
Yay Sanayi
Yemek Catering
Harita
Yemek Firmaları
Catering
Dedektif
Ziraat
Site Rehberi
Web Tasarımı
Arm Bilişim
Google Reklam
Firma Rehberi
Blank Clicks
Site Directory
Computers - Internet
Entertainment - Lifestyle
Internet Directory
Regional Directory
Company Directory
Financial - Legal

Anonymous said...

Thanks Best Regards
mirc
mirç
mırc
mırç
mircturk
turkmirc
mirc indir
mirc yukle
mirch
mırch
mirc turk
turk mirc
mırcturk
turkmırc
mırc turk
turk mırc
turkiyemirc
türkiyemirc
turkiye mirc
türkiye mirc
mircturkiye
mirctürkiye
mirc turkiye
mircturk
turkmırc
muhabbet
forum
forum
turkforum
turkiyeforum
mirc
turkmirc
toplist
site ekle
pagerank
turkmirc
turkforum
sohbet
chat
sohbet odaları
bedava sohbet
bedava chat
türk
karar

Anonymous said...

Play free game kanser youtube video directory oyun adult porno sex shop image hosting
japan auto store ara utube ytube video share online games adult

Kanser, akciğer kanseri, rahim kanseri -

Play game -
Play mario -
sim taxi -
Play game -
Adult oyun -
Play game -
Play game -
search -

video -
Youtube video -
About everything -
you tube video -
Youtube video -

Youtube Video -
Youtube Video -
Youtube Video -
Play free game kanser youtube video directory oyun adult porno sex shop image hosting
japan auto store ara mario games erotik fantazi fantezi iç giyim utube ytube
video share online games adult
Porn sex Video tube

Japan auto -
Youporn -
Sex shop -
Image hosting -
Image hosting -
Porn Video -
Porno Video -
Play free game kanser youtube video directory oyun adult porno sex shop image hosting
japan auto store ara mario games erotik fantazi fantezi iç giyim utube ytube
video share online games adult
Porno Video
Porn Video -
Youtube Video -
Sex Shop -
Sex Shop -
erotik iç giyim -
Sex Shop -
Video Hosting -
Porno Video -
Cancer, sex, video, games -
porno -
Directory -
Directory

Play free game kanser youtube video directory oyun adult porno sex shop image hosting
japan auto store ara mario games erotik fantazi fantezi iç giyim utube ytube
video share online games adult